Multiple Sclerosis: It’s in Your Head

Multiple sclerosis (MS) is a disease of the central nervous system that causes damage to your brain, spinal cord, and optic nerves. It’s characterized by lesions, or areas of tissue damage that occur when your immune system behaves abnormally and attacks these areas.

While many symptoms of MS throughout the body can be caused by lesions in either the brain or the spinal cord, cognitive symptoms of MS — those related to your memory, language, and problem solving — are believed to be caused only by lesions in the brain.

Brain lesions are a hallmark of MS, but they’re not the only way MS can affect your brain function. MS can also contribute to brain atrophy, or shrinkage, over time — a process that occurs in all people as they age, but typically happens much more quickly in people with MS. Brain atrophy, in particular, can contribute to cognitive symptoms of MS.

What Happens When MS Attacks the Brain

In most people who have MS, symptoms of the disease arrive or get worse suddenly during flares of disease activity. During an MS flare, “what we think happens is that there is inflammation coming in from the bloodstream, and that’s the first step in a relapse or new lesion” in the brain, explains Anne Cross, MD, a professor of neurology and MS specialist at Washington University School of Medicine in St. Louis.

According to Dr. Cross, this process involves immune system cells and other substances entering the brain and not just acting on their own, but also “recruiting” local cells to secrete pro-inflammatory substances in the area. Some of these cells and substances attack myelin, a white fatty substance that covers nerve fibers in the brain and elsewhere.

A nerve fiber (also known as an axon) is a long, narrow part of a nerve cell (neuron) that extends from the main body of the cell. It transmits signals from the nerve cell to other cells and tissues. Depending on the specific cell or tissue it connects to, a nerve cell can play a role in any number of the body’s normal functions, from thinking and talking to walking and moving your arms.

Myelin acts as a protective layer on the outside of nerve fibers. When this layer is damaged, nerve fibers can become exposed, which may cause them to transmit signals erratically or less efficiently.

“If you have an active MS lesion, under the microscope it would have lots of inflammatory cells there, and it would have greatly reduced myelin, but the nerve fibers would mostly still be there,” says Cross.

How Brain Lesions Form in MS

Sometimes, loss of myelin in the brain does nothing to interfere with nerve signals, says Cross. “It depends on how much of it is lost in a bundle of nerve fibers,” she explains. But when enough myelin is lost from enough nerve fibers in an area, this lesion will be visible on a magnetic resonance imaging (MRI) scan of the brain — and MS symptoms may develop.

Even without medical treatment, brain lesions in MS don’t simply keep growing and growing. “The body calms down these lesions and surrounds them, and they stop,” says Cross.

If a lesion forms but doesn’t develop past a certain point, it may cause few or even no symptoms. “You might see a region that’s demyelinated, but the nerve fibers are still there and haven’t been damaged too much,” Cross explains. “And that person may have no functional deficits from that lesion.”

But in some lesions, the nerve fibers themselves become heavily damaged and die off as a result. That stops the affected nerve cells from sending signals and can result in a permanent loss of cognitive or physical function.

• MRI scan of a healthy brain.
• Brain scans with multiple MS lesions.

Brain Atrophy: Why Volume Loss Is a Concern

All people tend to lose brain volume as they age — a process known as atrophy. But in people who have MS, this process typically happens much faster.

It’s normal to lose 0.1 to 0.5 percent of brain volume each year as you age. However, in people with MS, this range is typically 0.5 to 1.35 percent, according to an article published in September 2016 in the journal Multiple Sclerosis and Related Disorders. This greater atrophy may begin even before an MS diagnosis.

When nerve fibers die off in significant numbers due to an MS lesion, myelin is lost from the areas of the brain outside that lesion. That’s because nerve fibers can be very long, extending from one area of the brain to another. A lesion may affect only a small portion of a nerve fiber at first, but when the nerve fiber dies, myelin is lost from the entire length of that fiber beyond the lesion.

Neurologists commonly think about the brain as a mix of gray matter and white matter. Gray matter consists of the main bodies of nerve cells, while white matter consists of the nerve fibers that extend from these bodies. White matter gets its color from the myelin that surrounds nerve fibers. So when myelin is lost in areas outside lesions, it tends to cause atrophy of white matter.

But brain atrophy due to MS isn’t limited to white matter. Loss of nerve fibers can lead to the death of entire nerve cells, which means loss of the main nerve cell bodies that make up gray matter. This gray matter atrophy “is more associated with functional consequences than white matter atrophy” is, says Cross.

Scientists are still trying to figure out which symptoms are likely to be caused by atrophy of particular areas of the brain. “The human brain is so interconnected that it’s difficult to say, ‘This dysfunction is due to that region,’” Cross explains. “Memory and cognition are particularly difficult to pin down to any particular region.”

Cognitive Symptoms and Decline in MS

MS lesions in both the brain and spinal cord can cause a wide range of physical symptoms, including trouble with moving muscles, numbness and tingling, and reduced bladder control. But lesions in the brain — and especially gray matter atrophy in the brain — can also cause cognitive symptoms.

Cognitive symptoms in MS are often related to memory, says Cross — but not forgetting skills or information in the way that someone with dementia would. Instead, “many people with MS have trouble with multitasking, keeping two or three things going in their mind at the same time,” she explains.

The National MS Society published cognitive screening recommendations for people with MS in October 2018 in the Multiple Sclerosis Journal. These recommendations include getting a baseline cognitive screening as early as possible when your condition is clinically stable and then following up with the same mode of screening every year. Screening may also be repeated more often than once a year to assess the effects of a new or changed treatment, to evaluate progression of cognitive impairment, or to screen for new cognitive problems.

People who have MS may also experience reduced visual or verbal memory. “One of the tests I like to use is to take the word ‘world’ and ask patients to put the letters in alphabetical order, without using a piece of paper,” says Cross.

Many people who have MS describe their experience of cognitive problems as a kind of “fog” (cognitive fog, or “cog fog”) that makes it difficult to form certain thoughts or complete mental tasks.

Kathy Reagan Young

“It’s an inability to access information and words to express what I’m thinking or feeling. It affects my ability to understand — I get confused. It’s frustrating and scary.”

Host of podcast FUMS

Michael Wentink

“I’m regularly losing my train of thought, telling a story and forgetting why I started it, forgetting where I’m driving or even where I’m seated at a restaurant when I use the restroom.”

Blogger at A Life Less Traveled

Caroline Craven

“I know the thoughts are there in my mind. The words should form but they don’t. Visions cross my mind but no sense of order can be made of it all.”

Blogger at Girl with MS