We are excited to share the latest research insights from the Buffalo Neuroimaging Analysis Center (BNAC) presented at the ECTRIMS 2024 meeting in Copenhagen, Denmark. This year, BNAC showcased six compelling abstracts highlighting advancements in understanding multiple sclerosis (MS) through neuroimaging.
Below are the key takeaways two of the most notable presentations:
Characteristics of Long-Term Paramagnetic Rim Lesion Evolution and Clinical Trial Sample Size Calculations
Presented by: Jack Reeves, PhD
Paramagnetic rim lesions (PRLs) have emerged as an important imaging marker for assessing chronic active inflammation in MS, and as announced at this ECTRIMS, will be part of the new MS diagnostic criteria. Jack Reeves’ study analyzed the long-term evolution of PRLs in a cohort of MS patients, revealing the rates of PRL persistence, disappearance, and new appearance over a period of 5 to 10 years. A key takeaway was the estimation of required sample sizes for clinical trials using PRL rim disappearance or new PRL appearance as outcomes. The study highlighted that for moderate-efficacy drugs, very large cohorts are required when targeting PRL disappearance, whereas trials focusing on PRL appearance could be more feasible with higher efficacy treatments.
Chronic White Matter Inflammation and Choroid Plexus Volume in Progressive MS
Presented by: Ashley Tranquille, PhD Candidate
Chronic white matter inflammation is recognized as a key driver of MS progression. Ashley Tranquille’s study explored the association between chronic active inflammation and choroid plexus (CP) volume over five years in people with MS. Results showed that in people with progressive MS, baseline PRLs were associated with CP enlargement over the follow-up. This relationship suggests a link between chronic inflammation in both the white matter and the CP, a key barrier of the central nervous system. These findings help deepen our understanding of the role of CP in MS disease progression and could inform future therapeutic strategies aimed at targeting chronic inflammation.
These studies, along with four other insightful abstracts from BNAC, underscore the growing importance of advanced imaging techniques in understanding MS disease progression and informing clinical trial designs. Stay tuned for more updates as we continue to advance the frontiers of MS research!
Source: Buffalo Neuroimaging Analysis Center